Lot numbers can be found on the outside label of a product:
4-Chloro-6-methylquinoline
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CAS No. 18436-71-0
- Cat. No. CS-0116124
- Purity≥97%
- MDL No.None
*For research and further manufacturing use only, not for direct human use.
Structure of 18436-71-0
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General Information
- CAS No. 18436-71-0
- Cat. No. CS-0116124
- Purity ≥97%
- MDL No. None
- Storage Store at room temperature
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₁₀H₈ClN
- Molecular Weight 177.63
- Synonym(s) None
- SMILES CC1=CC=C2N=CC=C(Cl)C2=C1
Description
4-Chloro-6-methylquinoline is a heterocyclic scaffold featuring a chlorine substituent at the 4-position and a methyl group at the 6-position on the quinoline core. This configuration imparts enhanced electron-withdrawing character and steric influence, enabling its use in transition metal-catalyzed coupling reactions. The compound exhibits good stability under standard bench conditions and demonstrates favorable solubility in common organic solvents, facilitating integration into synthetic workflows for pharmaceutical intermediates and functional materials.
Application
4-Chloro-6-methylquinoline serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the C4 position via palladium-catalyzed cross-coupling reactions. Its methyl group at C6 enhances lipophilicity and metabolic stability, while the chloro substituent provides a reliable handle for late-stage diversification. The scaffold exhibits excellent bench stability and compatibility with standard purification methods, facilitating efficient synthesis of quinoline-based drug candidates and kinase inhibitors.
Synthesis
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Route1
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In-stock
23432-40-8 - ~%
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In-stock
18436-71-0
References
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US6281227 B1, ;
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Route2
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25063-44-9 - ~%
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In-stock
18436-71-0
References
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Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 4 p. 1015 - 1018
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Route3
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106-49-0 - ~%
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In-stock
18436-71-0
References
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European Journal of Medicinal Chemistry, , vol. 63, p. 907 - 923
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS05,GHS07
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Signal Word : Danger
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UN#: 1759
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Class : 8
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Packing Group : Ⅲ
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Hazard Statements : H302-H315-H318-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 12.89
- LogP 3.19662
- H_Acceptors 1
- H_Donors 0
- Rotatable_Bonds 0
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Key Words
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