4-Chloro-6-methylquinoline

Name: 4-Chloro-6-methylquinoline
Brand: ChemScene
Availability: InStock
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CAS No. 18436-71-0
Cat. No. CS-0116124
Purity≥97%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Structure of 18436-71-0

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Description

4-Chloro-6-methylquinoline is a heterocyclic scaffold featuring a chlorine substituent at the 4-position and a methyl group at the 6-position on the quinoline core. This configuration imparts enhanced electron-withdrawing character and steric influence, enabling its use in transition metal-catalyzed coupling reactions. The compound exhibits good stability under standard bench conditions and demonstrates favorable solubility in common organic solvents, facilitating integration into synthetic workflows for pharmaceutical intermediates and functional materials.

Application

4-Chloro-6-methylquinoline serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the C4 position via palladium-catalyzed cross-coupling reactions. Its methyl group at C6 enhances lipophilicity and metabolic stability, while the chloro substituent provides a reliable handle for late-stage diversification. The scaffold exhibits excellent bench stability and compatibility with standard purification methods, facilitating efficient synthesis of quinoline-based drug candidates and kinase inhibitors.

General Information

CAS No. 18436-71-0
Cat. No. CS-0116124
Purity ≥97%
MDL No. None
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₀H₈ClN
Molecular Weight 177.63
Synonym(s) None
SMILES CC1=CC=C2N=CC=C(Cl)C2=C1

Computational Chemistry Data

TPSA 12.89
LogP 3.19662
H_Acceptors 1
H_Donors 0
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS05,GHS07
Signal Word : Danger	UN#: 1759
Class : 8	Packing Group : Ⅲ
Hazard Statements : H302-H315-H318-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds quinoline compounds

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4-Chloro-6-methylquinoline

CAS No. 18436-71-0

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