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CS-W001157 4
Total: USD 88.00

4-Methylmorpholin-2-one

  • CAS No. 18424-96-9

  • Cat. No. CS-W001837
  • Purity≥96%
  • MDL No.MFCD16659615

*For research and further manufacturing use only, not for direct human use.

4-Methylmorpholin-2-one|CS-W001837

Structure of 18424-96-9

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General Information

  • CAS No. 18424-96-9
  • Cat. No. CS-W001837
  • Purity ≥96%
  • MDL No. MFCD16659615
  • Storage -20°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₉NO₂
  • Molecular Weight 115.13
  • Synonym(s) N-Methyl-2-oxomorpholine
  • SMILES CN1CCOC(=O)C1

Description

4-Methylmorpholin-2-one is a bench-stable, moisture-tolerant heterocyclic lactam featuring a sterically hindered carbonyl group. This structure enables efficient coupling in amide bond formation and serves as a robust scaffold for synthetic intermediates in medicinal chemistry.

Application

4-Methylmorpholin-2-one serves as a versatile building block in synthetic organic chemistry, enabling efficient access to nitrogen-containing heterocycles and bioactive scaffolds. Its cyclic amide functionality exhibits favorable bench stability and moderate nucleophilicity, facilitating selective transformations under mild conditions. The molecule functions effectively in coupling reactions and as a precursor in the construction of complex pharmaceutical intermediates, offering reliable reactivity with broad functional group tolerance.

Synthesis

  • Route1
    • N-(2-Hydroxyethyl)-N-methylglycine|CS-0661185
      26294-19-9
    • ~%
    • In-stock
      4-Methylmorpholin-2-one|CS-W001837
      18424-96-9

    References

    • Justus Liebigs Annalen der Chemie, , vol. 307, p. 203
  • Route2
    • null|null
      30083-12-6
    • ~%
    • In-stock
      4-Methylmorpholin-2-one|CS-W001837
      18424-96-9

    References

    • Bulletin de la Societe Chimique de France, , p. 2529 - 2534
  • Route3
    • null|null
      3053-29-0
    • ~%
    • In-stock
      4-Methylmorpholin-2-one|CS-W001837
      18424-96-9

    References

    • Bulletin de la Societe Chimique de France, , p. 2529 - 2534

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   29.54
  • LogP   -0.525
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   0

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