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CS-W001157 4
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Methyl 3-indoleglyoxylate

  • CAS No. 18372-22-0

  • Cat. No. CS-B0429
  • Purity≥96%
  • MDL No.MFCD00047173

*For research and further manufacturing use only, not for direct human use.

Methyl 3-indoleglyoxylate|CS-B0429

Structure of 18372-22-0

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General Information

  • CAS No. 18372-22-0
  • Cat. No. CS-B0429
  • Purity ≥96%
  • MDL No. MFCD00047173
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₉NO₃
  • Molecular Weight 203.19
  • Synonym(s) Methylindole-3-glyoxylate
  • SMILES O=C(C(OC)=O)C1=CNC2=CC=CC=C12

Application

Methyl 3-indoleglyoxylate serves as a versatile building block in synthetic organic chemistry, enabling efficient access to indole-containing scaffolds via classic condensation and cycloaddition reactions. Its glyoxylate functionality facilitates nucleophilic addition and subsequent transformations, including the synthesis of substituted indoles and heterocyclic systems. The methyl ester group enhances bench stability and simplifies purification, while the indole core provides inherent structural relevance for medicinal chemistry applications.

Synthesis

  • Route1
    • null|null
      67-56-1
    • In-stock
      3-Indoleglyoxylic acid|CS-0001919
      1477-49-2
    • ~87%
    • In-stock
      Methyl 3-indoleglyoxylate|CS-B0429
      18372-22-0

    References

    • European Journal of Medicinal Chemistry, , vol. 34, # 2 p. 161 - 165
  • Route2
    • null|null
      22980-09-2
    • null|null
      124-41-4
    • ~%
    • In-stock
      Methyl 3-indoleglyoxylate|CS-B0429
      18372-22-0

    References

    • Journal of Organic Chemistry, , vol. 63, # 17 p. 6053 - 6058
  • Route3
    • Indole, ≥99%|CS-1268948
      120-72-9
    • ~%
    • In-stock
      Methyl 3-indoleglyoxylate|CS-B0429
      18372-22-0

    References

    • Journal of Organic Chemistry, , vol. 23, p. 1171,1176

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   59.16
  • LogP   1.5236
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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