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CS-W001157 4
Total: USD 88.00

tert-Butyl N-(4-methylphenyl)sulfonylcarbamate

  • CAS No. 18303-04-3

  • Cat. No. CS-0037692
  • Purity≥96%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

tert-Butyl N-(4-methylphenyl)sulfonylcarbamate|CS-0037692

Structure of 18303-04-3

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General Information

  • CAS No. 18303-04-3
  • Cat. No. CS-0037692
  • Purity ≥96%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₇NO₄S
  • Molecular Weight 271.33
  • Synonym(s) N-BOC-Toluenesulfonamide
  • SMILES CC1=CC=C(C=C1)S(=O)(=O)N=C(O)OC(C)(C)C

Description

N-(tert-Butoxycarbonyl)-p-toluenesulfonamide is a N-substituted sulphonamide and its reaction with N-trityl L-serine esters under Mitsunobu reaction conditions is reported. It can be directly coupled with primary, secondary and allylic alcohols under Mitsunobu conditions to afford various sulfonyl-protected amines.N-(tert-Butoxycarbonyl)-p-toluenesulfonamide may be used in the preparation of enyne amide, precursor for Pauson-Khand reaction.

Synthesis

  • Route1

    References

    • Nouria, Azita; Akbari, Jafar; Heydaric, Akbar; Nouri, Arezu Letters in Organic Chemistry, 2011 , vol. 8, # 1 p. 38 - 42
  • Route2
    • In-stock
      p-Toluenesulfonyl Isocyanate|CS-0622162
      4083-64-1
    • null|null
      75-65-0
    • ~96%
    • In-stock
      tert-Butyl N-(4-methylphenyl)sulfonylcarbamate|CS-0037692
      18303-04-3

    References

    • Moore, Joel D; Harned, Andrew M; Henle, Julia; Flynn, Daniel L; Hanson, Paul R Organic letters, 2002 , vol. 4, # 11 p. 1847 - 1849
  • Route3
    • null|null
      170948-10-4
    • ~95%
    • In-stock
      tert-Butyl N-(4-methylphenyl)sulfonylcarbamate|CS-0037692
      18303-04-3

    References

    • Johnson II, David C.; Widlanski, Theodore S. Tetrahedron Letters, 2004 , vol. 45, # 46 p. 8483 - 8487

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P302+P352

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Computational Chemistry Data

  • TPSA   75.96
  • LogP   2.41282
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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