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CS-W001157 4
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4-(Hydroxymethyl)-2-methylphenol

  • CAS No. 18299-15-5

  • Cat. No. CS-0153185
  • Purity≥97%
  • MDL No.MFCD00238619

*For research and further manufacturing use only, not for direct human use.

4-(Hydroxymethyl)-2-methylphenol|CS-0153185

Structure of 18299-15-5

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General Information

  • CAS No. 18299-15-5
  • Cat. No. CS-0153185
  • Purity ≥97%
  • MDL No. MFCD00238619
  • Storage RT, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₀O₂
  • Molecular Weight 138.16
  • Synonym(s) 4-HYDROXY-3-METHYLBENZYL ALCOHOL
  • SMILES CC1=CC(=CC=C1O)CO

Description

4-(Hydroxymethyl)-2-methylphenol features a hydroxymethyl group flanked by a methyl substituent and phenolic OH on a benzene ring. This ortho-substituted structure enhances solubility and reactivity, enabling direct incorporation into synthetic routes requiring polar side chains. The compound serves as a stable, bench-ready precursor for functionalized aromatic intermediates in pharmaceutical and agrochemical development.

Application

4-(Hydroxymethyl)-2-methylphenol serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the phenolic OH and benzylic CH₂OH sites. Its dual reactivity facilitates derivatization via etherification, oxidation to aldehyde, or coupling reactions, supporting the construction of complex heterocyclic scaffolds and bioactive molecules. Bench-stable and readily purified by recrystallization, it functions efficiently in standard synthetic workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   40.46
  • LogP   1.19292
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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