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Methyl 2-(4-aminophenyl)-2-hydroxyacetate

  • CAS No. 182918-73-6

  • Cat. No. CS-0371106
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

Methyl 2-(4-aminophenyl)-2-hydroxyacetate|CS-0371106

Structure of 182918-73-6

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General Information

  • CAS No. 182918-73-6
  • Cat. No. CS-0371106
  • Purity ≥95%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₁NO₃
  • Molecular Weight 181.19
  • Synonym(s) (4-Amino-phenyl)-hydroxy-acetic acid methyl ester
  • SMILES O=C(C(C1=CC=C(C=C1)N)O)OC

Description

Methyl 2-(4-aminophenyl)-2-hydroxyacetate features a phenolic hydroxyl group and a primary amine in para configuration, enabling dual functionalization. This scaffold integrates readily into conjugation workflows and serves as a key intermediate for bioactive compound synthesis under standard conditions.

Application

Methyl 2-(4-aminophenyl)-2-hydroxyacetate serves as a versatile building block for the synthesis of bioactive heterocycles and pharmaceutical intermediates. Its ortho-hydroxyacetate functionality enables facile cyclization reactions, while the para-aminophenyl group offers direct handle for derivatization via coupling or electrophilic substitution. The compound exhibits good bench stability and is compatible with a range of standard synthetic transformations, facilitating efficient access to complex scaffolds in medicinal chemistry workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   72.55
  • LogP   0.4752
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   2

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