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CS-W001157 4
Total: USD 88.00

3-Bromo-2-hydroxybenzaldehyde

  • CAS No. 1829-34-1

  • Cat. No. CS-W007415
  • Purity≥98%
  • MDL No.MFCD00016587

*For research and further manufacturing use only, not for direct human use.

3-Bromo-2-hydroxybenzaldehyde|CS-W007415

Structure of 1829-34-1

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General Information

  • CAS No. 1829-34-1
  • Cat. No. CS-W007415
  • Purity ≥98%
  • MDL No. MFCD00016587
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₅BrO₂
  • Molecular Weight 201.02
  • Synonym(s) 2-Hydroxy-3-brom; 3-Bromo-2-hydroxybenzaldehyde
  • SMILES C1=CC=C(C(=C1C=O)O)Br

Description

It is applied in organic synthesis, lacquers, polyester adhesives, and urethane elastomers. Azelaic acid directly inhibits kallikrein 5 (KLK5), down regulating expression of KLK5, toll-like receptor 2 (TLR 2), and cathelicidin, and suppresses activity of serine proteases. In PUFA-treated fibroblasts, azelaic acid decreases generation of ROS and up regulates expression of antioxidative enzymes, inhibiting cell damage; agonist activity at PPAR? is thought to drive these effects. Azelaic acid also inhibits proliferation of melanocytes.

Synthesis

  • Route1
    • 7-Bromo-2-methylbenzofuran|CS-0453790
      57547-15-6
    • ~78%
    • In-stock
      3-Bromo-2-hydroxybenzaldehyde|CS-W007415
      1829-34-1

    References

    • Magnin, David R.; Sulsky, Richard B.; Robl, Jeffrey A.; Caulfield, Thomas J.; Parker, Rex A. Patent: US2003/225091 A1, 2003 ; Location in patent: Page 29 ;
  • Route2
    • null|null
      50-00-0
    • null|null
      95-56-7
    • ~99%
    • In-stock
      3-Bromo-2-hydroxybenzaldehyde|CS-W007415
      1829-34-1

    References

    • GLAXO GROUP LIMITED Patent: WO2007/118130 A2, 2007 ; Location in patent: Page/Page column 28 ;
  • Route3
    • null|null
      95-56-7
    • ~%
    • In-stock
      3-Bromo-2-hydroxybenzaldehyde|CS-W007415
      1829-34-1

    References

    • Journal of Medicinal Chemistry, , vol. 45, # 17 p. 3573 - 3575

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   37.3
  • LogP   1.9672
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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