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CS-W001157 4
Total: USD 88.00

1-Ethyl-2-iodobenzene

  • CAS No. 18282-40-1

  • Cat. No. CS-0109507
  • Purity≥98%
  • MDL No.MFCD00040871

*For research and further manufacturing use only, not for direct human use.

1-Ethyl-2-iodobenzene|CS-0109507

Structure of 18282-40-1

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General Information

  • CAS No. 18282-40-1
  • Cat. No. CS-0109507
  • Purity ≥98%
  • MDL No. MFCD00040871
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₉I
  • Molecular Weight 232.06
  • Synonym(s) 2-ETHYLIODOBENZENE
  • SMILES IC1=CC=CC=C1CC

Description

1-Ethyl-2-iodobenzene is a bench-stable aryl iodide featuring a para-substituted ethyl group that enhances solubility in organic media. This compound serves as a reliable coupling partner in palladium-catalyzed cross-coupling reactions, where the iodine atom facilitates efficient bond formation under standard conditions.

Application

1-Ethyl-2-iodobenzene serves as a versatile aryl iodide building block in transition-metal-catalyzed cross-coupling reactions. Its ortho-ethyl substitution provides steric and electronic modulation, enhancing regioselectivity in Pd-catalyzed couplings. The compound exhibits good bench stability, facilitates straightforward purification, and functions reliably in Suzuki, Stille, and Negishi reactions, enabling efficient construction of biaryl and complex heterocyclic scaffolds.

Synthesis

  • Route1
    • null|null
      128254-34-2
    • ~%
    • In-stock
      1-Ethyl-2-iodobenzene|CS-0109507
      18282-40-1

    References

    • Tetrahedron Letters, , vol. 31, # 43 p. 6179 - 6182
  • Route2
    • null|null
      100-41-4
    • ~%
    • In-stock
      1-Ethyl-4-iodobenzene|CS-0109504
      25309-64-2
    • In-stock
      1-Ethyl-2-iodobenzene|CS-0109507
      18282-40-1

    References

    • Russian Journal of Organic Chemistry, , vol. 36, # 5 p. 666 - 670
  • Route3
    • null|null
      578-54-1
    • ~%
    • In-stock
      1-Ethyl-2-iodobenzene|CS-0109507
      18282-40-1

    References

    • Chemische Berichte, , vol. 89, p. 1994,1998

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352

Quality Control

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Computational Chemistry Data

  • TPSA   0
  • LogP   2.8536
  • H_Acceptors   0
  • H_Donors   0
  • Rotatable_Bonds   1

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