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CS-W001157 4
Total: USD 88.00

1-Ethyl-4-iodobenzene

  • CAS No. 25309-64-2

  • Cat. No. CS-0109504
  • Purity≥98%
  • MDL No.MFCD00060663

*For research and further manufacturing use only, not for direct human use.

1-Ethyl-4-iodobenzene|CS-0109504

Structure of 25309-64-2

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General Information

  • CAS No. 25309-64-2
  • Cat. No. CS-0109504
  • Purity ≥98%
  • MDL No. MFCD00060663
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₉I
  • Molecular Weight 232.06
  • Synonym(s) 4-Ethyliodobenzene
  • SMILES IC1=CC=C(CC)C=C1

Description

2-Bromo-4,5-difluorophenylacetic acid is used as intermediate in organic syntheses.

Application

1-Ethyl-4-iodobenzene serves as a versatile aryl halide building block in palladium-catalyzed cross-coupling reactions, enabling efficient C–C bond formation under standard Suzuki, Stille, and Negishi conditions. The ethyl substituent provides moderate steric and electronic modulation, enhancing solubility and stability during synthesis. Bench-stable and readily purified by column chromatography, it functions reliably in the construction of biaryl scaffolds and functionalized arenes relevant to pharmaceutical and materials chemistry.

Synthesis

  • Route1

    References

    • Sakai, Norio; Nagasawa, Ken; Ikeda, Reiko; Nakaike, Yumi; Konakahara, Takeo Tetrahedron Letters, 2011 , vol. 52, # 24 p. 3133 - 3136
  • Route2
    • null|null
      100-41-4
    • ~72%
    • In-stock
      1-Ethyl-4-iodobenzene|CS-0109504
      25309-64-2

    References

    • Chaikovskii; Novikov Journal of applied chemistry of the USSR, 1984 , vol. 57, # 1 pt 2 p. 121 - 123
  • Route3
    • null|null
      96227-75-7
    • ~70%
    • In-stock
      1-Ethyl-4-iodobenzene|CS-0109504
      25309-64-2

    References

    • Patrick, Timothy B.; Juehne, Thomas; Reeb, Elmer; Hennessy, Daniel Tetrahedron Letters, 2001 , vol. 42, # 21 p. 3553 - 3554

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   0
  • LogP   2.8536
  • H_Acceptors   0
  • H_Donors   0
  • Rotatable_Bonds   1

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