(1S,2S)-2-(Difluoromethyl)cyclopropanecarboxylic acid

Name: (1S,2S)-2-(Difluoromethyl)cyclopropanecarboxylic acid
Brand: ChemScene
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CAS No. 1820569-46-7
Cat. No. CS-0312499
Purity≥95%
MDL No.None

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Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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(1S,2S)-2-(Difluoromethyl)cyclopropanecarboxylic acid|CS-0312499

Structure of 1820569-46-7

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General Information

CAS No. 1820569-46-7
Cat. No. CS-0312499
Purity ≥95%
MDL No. None
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₆F₂O₂
Molecular Weight 136.10
Synonym(s) (1S,2S)-2-(Difluoromethyl)cyclopropane-1-carboxylic acid
SMILES FC([C@@H]1[C@H](C1)C(O)=O)F

Description

This difluoromethyl-substituted cyclopropane carboxylic acid features a strained, rigid scaffold with enhanced metabolic stability. The electron-withdrawing difluoromethyl group imparts strong acidity and modulates lipophilicity, enabling effective incorporation into bioactive molecules. Designed for medicinal chemistry applications, this building block facilitates the development of novel therapeutics through improved pharmacokinetic profiles.

Application

(1S,2S)-2-(Difluoromethyl)cyclopropanecarboxylic acid serves as a valuable chiral building block in medicinal chemistry, enabling the introduction of a rigid, electron-deficient difluoromethylcyclopropane motif. Its stability under standard synthetic conditions and compatibility with common functional groups facilitate incorporation into bioactive scaffolds, particularly in CNS-targeted compounds and enzyme inhibitors.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

TPSA 37.3
LogP 0.9722
H_Acceptors 1
H_Donors 1
Rotatable_Bonds 2

Other Classifications

Building Blocks Functional Group Carboxylic Acid

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Building Blocks Skeleton Fatty ring compounds Cyclopropane compounds

Key Words

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(1S,2S)-2-(Difluoromethyl)cyclopropanecarboxylic acid

CAS No. 1820569-46-7

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