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CS-W001157 4
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1-Methylazetidin-3-one hydrochloride

  • CAS No. 1818847-43-6

  • Cat. No. CS-0052428
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

1-Methylazetidin-3-one hydrochloride|CS-0052428

Structure of 1818847-43-6

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General Information

  • CAS No. 1818847-43-6
  • Cat. No. CS-0052428
  • Purity ≥95%
  • MDL No. None
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₈ClNO
  • Molecular Weight 121.57
  • Synonym(s) 1-Methylazetidine-3-onehydrochloride
  • SMILES Cl.CN1CC(=O)C1

Description

1-Methylazetidin-3-one hydrochloride is a bench-stable, moisture-tolerant heterocyclic amide featuring a strained four-membered ring system. This compact scaffold integrates readily into medicinal chemistry libraries, delivering enhanced metabolic stability and improved solubility in polar solvents. Its electron-deficient carbonyl group facilitates nucleophilic addition reactions under mild conditions.

Application

1-Methylazetidin-3-one hydrochloride serves as a stable, bench-ready building block for medicinal chemistry and process development. Its strained four-membered lactam ring enables efficient functionalization at the C3 position and facilitates coupling reactions with nucleophiles under mild conditions. The N-methyl group enhances metabolic stability and modulates solubility, while the hydrochloride salt improves crystallinity and handling. Widely used in the synthesis of bioactive heterocycles, it functions as a key intermediate in constructing azetidine-based scaffolds found in pharmaceutical candidates.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

Quality Control

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Computational Chemistry Data

  • TPSA   20.31
  • LogP   -0.0773
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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