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(S)-2-Amino-2-(4-chloro-3-(trifluoromethyl)phenyl)ethanol hydrochloride

  • CAS No. 1810074-79-3

  • Cat. No. CS-0158635
  • Purity≥98%
  • MDL No.MFCD12758208

*For research and further manufacturing use only, not for direct human use.

(S)-2-Amino-2-(4-chloro-3-(trifluoromethyl)phenyl)ethanol hydrochloride|CS-0158635

Structure of 1810074-79-3

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General Information

  • CAS No. 1810074-79-3
  • Cat. No. CS-0158635
  • Purity ≥98%
  • MDL No. MFCD12758208
  • Storage 4°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₀Cl₂F₃NO
  • Molecular Weight 276.08
  • Synonym(s) (S)-2-amino-2-(4-chloro-3-(trifluoromethyl)phenyl)ethan-1-ol hydrochloride
  • SMILES [C@H](CO)(N)C=1C=C(C(=CC1)Cl)C(F)(F)F.Cl

Description

(S)-2-Amino-2-(4-chloro-3-(trifluoromethyl)phenyl)ethanol hydrochloride is a chiral building block featuring a sterically hindered amino alcohol scaffold. The para-chloro and trifluoromethyl groups on the aryl ring enhance electron deficiency and metabolic stability. This bench-stable salt integrates readily into asymmetric synthesis workflows for pharmaceutical intermediates.

Application

(S)-2-Amino-2-(4-chloro-3-(trifluoromethyl)phenyl)ethanol hydrochloride serves as a chiral building block for synthesizing bioactive molecules, particularly in medicinal chemistry. Its well-defined stereochemistry and functional group tolerance enable reliable incorporation into pharmaceutical intermediates. The molecule exhibits bench stability and facilitates efficient coupling reactions, making it valuable for API development workflows requiring high enantiomeric purity and predictable reactivity.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   46.25
  • LogP   2.7727
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   2

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