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CS-W001157 4
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(2,4-Difluoro-6-methoxyphenyl)boronic acid

  • CAS No. 1808997-86-5

  • Cat. No. CS-0490419
  • Purity≥96%
  • MDL No.MFCD22414936

*For research and further manufacturing use only, not for direct human use.

(2,4-Difluoro-6-methoxyphenyl)boronic acid|CS-0490419

Structure of 1808997-86-5

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General Information

  • CAS No. 1808997-86-5
  • Cat. No. CS-0490419
  • Purity ≥96%
  • MDL No. MFCD22414936
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇BF₂O₃
  • Molecular Weight 187.94
  • Synonym(s) None
  • SMILES COC1C(B(O)O)=C(F)C=C(F)C=1

Description

This boronate moiety integrates a 2,4-difluoro-6-methoxyphenyl scaffold, offering enhanced stability and solubility in polar solvents. The electron-deficient aryl core enables efficient coupling under standard Suzuki-Miyaura conditions, while the methoxy group improves handling and reduces protodeboronation.

Application

(2,4-Difluoro-6-methoxyphenyl)boronic acid serves as a versatile building block in Suzuki-Miyaura cross-coupling reactions, enabling efficient construction of biaryl architectures under mild conditions. The ortho-difluoro substitution enhances electrophilic reactivity and facilitates downstream functionalization, while the methoxy group provides steric and electronic modulation. Bench-stable and readily purified by recrystallization, it exhibits excellent functional group tolerance, making it ideal for late-stage diversification in medicinal chemistry and materials synthesis.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362+P364

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Computational Chemistry Data

  • TPSA   49.69
  • LogP   -0.3468
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   2

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