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CS-W001157 4
Total: USD 88.00

Br-PEG4-CH2-Boc

  • CAS No. 1807505-29-8

  • Cat. No. CS-0108896
  • Molecule weight371.26
  • Purity≥97%
  • MDL No.MFCD27977496

*For research and further manufacturing use only, not for direct human use.

Br-PEG4-CH2-Boc|CS-0108896

Structure of 1807505-29-8

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General Information

  • CAS No. 1807505-29-8
  • Cat. No. CS-0108896
  • Purity ≥97%
  • MDL No. MFCD27977496
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₄H₂₇BrO₆
  • Molecular Weight 371.26
  • Synonym(s) None
  • SMILES O=C(OC(C)(C)C)COCCOCCOCCOCCBr

Description

Br-PEG4-CH2-Boc features a bromide-functionalized PEG4 spacer linked to a Boc-protected amine via a methylene bridge. This bifunctional reagent enables site-specific conjugation in synthetic chemistry, combining excellent solubility with orthogonal protection. The pendant bromide facilitates nucleophilic substitution, while the Boc group remains stable under basic conditions and can be selectively removed for downstream coupling.

Application

Br-PEG4-CH2-Boc serves as a versatile bifunctional building block for conjugation and protection strategies in synthetic organic chemistry. The bromide group enables efficient nucleophilic substitution reactions, while the PEG4 spacer provides solubility and reduced aggregation. The Boc group offers reliable protection of primary amines, removable under mild acidic conditions. This compound facilitates site-specific derivatization in peptide synthesis, macrocycle formation, and the construction of bioconjugates with enhanced stability and handling properties.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   63.22
  • LogP   1.7894
  • H_Acceptors   6
  • H_Donors   0
  • Rotatable_Bonds   13

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