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CS-W001157 4
Total: USD 88.00

2,6-Bis(trifluoromethyl)benzoic acid

  • CAS No. 24821-22-5

  • Cat. No. CS-W010161
  • Purity≥98%
  • MDL No.MFCD00000376

*For research and further manufacturing use only, not for direct human use.

2,6-Bis(trifluoromethyl)benzoic acid|CS-W010161

Structure of 24821-22-5

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General Information

  • CAS No. 24821-22-5
  • Cat. No. CS-W010161
  • Purity ≥98%
  • MDL No. MFCD00000376
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₄F₆O₂
  • Molecular Weight None
  • Synonym(s) 2,6-bis(trifluoromethyl)benzoate
  • SMILES OC(=O)C1=C(C=CC=C1C(F)(F)F)C(F)(F)F

Description

t-Boc-N-amido-PEG3-CH2CO2H is a PEG linker containing a terminal carboxylic acid and Boc-protected amino group. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.

Synthesis

  • Route1
    • null|null
      124-38-9
    • null|null
      402-31-3
    • ~91%
    • In-stock
      2,6-Bis(trifluoromethyl)benzoic acid|CS-W010161
      24821-22-5

    References

    • Schlosser, Manfred; Mongin; Porwisiak, Jacek; Dmowski, Wojciech; Bueker, Heinz H.; Nibbering, Nico M. M. Chemistry - A European Journal, 1998 , vol. 4, # 7 p. 1281 - 1286
  • Route2
    • null|null
      42175-48-4
    • ~%
    • In-stock
      2,6-Bis(trifluoromethyl)benzoic acid|CS-W010161
      24821-22-5

    References

    • Journal of Organic Chemistry USSR (English Translation), , vol. 13, # 10 p. 1979 - 1985 Zhurnal Organicheskoi Khimii, , vol. 13, # 10 p. 2129 - 2135
  • Route3

    References

    • Tetrahedron, , vol. 55, # 4 p. 909 - 918

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352

Quality Control

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Computational Chemistry Data

  • TPSA   37.3
  • LogP   3.4224
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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