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Methyl 6-bromo-2-oxo-1,2-dihydropyridine-3-carboxylate

  • CAS No. 1807201-84-8

  • Cat. No. CS-0160538
  • Purity≥97%
  • MDL No.MFCD30721037

*For research and further manufacturing use only, not for direct human use.

Methyl 6-bromo-2-oxo-1,2-dihydropyridine-3-carboxylate|CS-0160538

Structure of 1807201-84-8

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General Information

  • CAS No. 1807201-84-8
  • Cat. No. CS-0160538
  • Purity ≥97%
  • MDL No. MFCD30721037
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆BrNO₃
  • Molecular Weight 232.03
  • Synonym(s) Methyl 6-bromo-2-oxo-1,2-dihydro-3-pyridinecarboxylate
  • SMILES O=C(C1=CC=C(Br)NC1=O)OC

Description

Methyl 6-bromo-2-oxo-1,2-dihydropyridine-3-carboxylate features a brominated dihydropyridine core with a carbonyl at C2 and an ester at C3, enabling direct functionalization in heterocyclic synthesis. This bench-stable reagent integrates readily into transition-metal-catalyzed couplings and serves as a key intermediate for bioactive pyridine derivatives.

Application

Methyl 6-bromo-2-oxo-1,2-dihydropyridine-3-carboxylate serves as a versatile building block in heterocyclic synthesis, enabling efficient access to substituted pyridine scaffolds. The bromo group facilitates palladium-catalyzed cross-coupling reactions, while the ester and enone functionalities support nucleophilic additions and further functionalization. Its bench-stable nature and compatibility with standard reaction conditions make it well-suited for medicinal chemistry and process development workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   59.16
  • LogP   0.924
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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