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CS-W001157 4
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4-Bromo-2-fluoro-5-iodopyridine

  • CAS No. 1807119-09-0

  • Cat. No. CS-0130945
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

4-Bromo-2-fluoro-5-iodopyridine|CS-0130945

Structure of 1807119-09-0

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General Information

  • CAS No. 1807119-09-0
  • Cat. No. CS-0130945
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₂BrFIN
  • Molecular Weight 301.88
  • Synonym(s) 4-Bromo-2-fluoro-5-iodo-pyridine
  • SMILES IC1=CN=C(F)C=C1Br

Description

4-Bromo-2-fluoro-5-iodopyridine is a trihalogenated pyridine scaffold featuring strategically positioned bromo, fluoro, and iodo substituents. This electron-deficient heteroaromatic core enables efficient cross-coupling reactions in palladium-catalyzed transformations. The orthogonal reactivity of the halogens supports sequential functionalization, making this compound a valuable building block for advanced pharmaceutical intermediates and materials synthesis.

Application

4-Bromo-2-fluoro-5-iodopyridine serves as a versatile trihalogenated pyridine building block for cross-coupling reactions, enabling sequential functionalization in medicinal chemistry and materials science. The strategic placement of bromo, fluoro, and iodo substituents supports orthogonal reactivity in Pd-catalyzed transformations, with the iodide site typically undergoing selective coupling under mild conditions. Bench-stable and compatible with standard purification methods, it facilitates efficient access to complex heterocyclic scaffolds and diversification of API candidates through modular synthesis.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H227-H315-H319-H335
Precautionary Statements : P210-P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P370+P378-P403-P405-P501

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   2.5878
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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