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CS-W001157 4
Total: USD 88.00

5-Bromo-2-fluoro-3-iodopyridine

  • CAS No. 1214376-88-1

  • Cat. No. CS-0145307
  • Purity≥95%
  • MDL No.MFCD13185373

*For research and further manufacturing use only, not for direct human use.

5-Bromo-2-fluoro-3-iodopyridine|CS-0145307

Structure of 1214376-88-1

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General Information

  • CAS No. 1214376-88-1
  • Cat. No. CS-0145307
  • Purity ≥95%
  • MDL No. MFCD13185373
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₂BrFIN
  • Molecular Weight 301.88
  • Synonym(s) 2-fluoro-5-broMo-3-iodopyridine
  • SMILES IC1=CC(Br)=CN=C1F

Description

5-Bromo-2-fluoro-3-iodopyridine features a trihalogenated pyridine core with distinct halogen positions enabling selective cross-coupling reactions. The electron-deficient ring facilitates palladium-catalyzed transformations, while the orthogonal reactivity of bromo, fluoro, and iodo substituents allows sequential functionalization. This compound serves as a key building block in the synthesis of bioactive heterocycles and advanced pharmaceutical intermediates.

Application

5-Bromo-2-fluoro-3-iodopyridine serves as a versatile trihalogenated pyridine building block for palladium-catalyzed cross-coupling reactions. The strategically positioned bromo, fluoro, and iodo substituents enable sequential functionalization with high regiocontrol, facilitating the synthesis of complex heterocyclic scaffolds. Its bench-stable nature and compatibility with standard coupling conditions make it well-suited for iterative C–C and C–heteroatom bond formation in medicinal chemistry and materials science applications.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

Quality Control

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   2.5878
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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