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CS-W001157 4
Total: USD 88.00

3-(Difluoromethyl)-2(1H)-pyridinone

  • CAS No. 1806766-03-9

  • Cat. No. CS-0650460
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

3-(Difluoromethyl)-2(1H)-pyridinone|CS-0650460

Structure of 1806766-03-9

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General Information

  • CAS No. 1806766-03-9
  • Cat. No. CS-0650460
  • Purity ≥95%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅F₂NO
  • Molecular Weight 145.11
  • Synonym(s) None
  • SMILES O=C1C(C(F)F)=CC=CN1

Description

3-(Difluoromethyl)-2(1H)-pyridinone features a strategically positioned difluoromethyl group that enhances metabolic stability and modulates electronic properties. This electron-deficient pyridinone scaffold integrates readily into bioactive molecules, serving as a key pharmacophore in medicinal chemistry. Its bench-stable nature supports reliable handling and incorporation under standard conditions.

Application

3-(Difluoromethyl)-2(1H)-pyridinone serves as a versatile building block in medicinal chemistry, enabling direct introduction of a difluoromethyl group into bioactive scaffolds. Its pyridinone core offers enhanced metabolic stability and favorable polarity, while the difluoromethyl substituent imparts strong electron-withdrawing character and improved membrane permeability. The compound exhibits bench stability and compatibility with standard coupling reactions, facilitating downstream functionalization in drug discovery campaigns.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

Quality Control

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Computational Chemistry Data

  • TPSA   32.86
  • LogP   1.3125
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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