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CS-W001157 4
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1-(Difluoromethyl)cyclopropan-1-amine hydrochloride

  • CAS No. 1803595-15-4

  • Cat. No. CS-0063280
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

1-(Difluoromethyl)cyclopropan-1-amine hydrochloride|CS-0063280

Structure of 1803595-15-4

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General Information

  • CAS No. 1803595-15-4
  • Cat. No. CS-0063280
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₈ClF₂N
  • Molecular Weight 143.56
  • Synonym(s) None
  • SMILES NC1(C(F)F)CC1.[H]Cl

Description

This difluoromethylcyclopropane derivative features a sterically constrained cyclopropane ring bearing a difluoromethyl group and a primary amine, stabilized as its hydrochloride salt. The electron-withdrawing fluorine atoms enhance metabolic stability while preserving nucleophilic reactivity of the amine. This bench-stable crystalline solid integrates readily into medicinal chemistry libraries for probing bioisosteric effects in CNS-targeted compounds.

Application

1-(Difluoromethyl)cyclopropan-1-amine hydrochloride serves as a versatile building block for fluorinated bioactive molecules, enabling direct incorporation of the difluoromethyl group into medicinal chemistry scaffolds. The cyclopropane ring imparts conformational rigidity, while the amine functionality facilitates straightforward derivatization and salt formation. Its bench-stable hydrochloride form ensures ease of handling, purification, and compatibility with standard peptide coupling and reductive amination protocols in synthetic workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   26.02
  • LogP   1.1646
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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