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CS-W001157 4
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(S)-4-Phenyl-2-(5-(trifluoromethyl)pyridin-2-yl)-4,5-dihydrooxazole

  • CAS No. 1803416-28-5

  • Cat. No. CS-0097613
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(S)-4-Phenyl-2-(5-(trifluoromethyl)pyridin-2-yl)-4,5-dihydrooxazole|CS-0097613

Structure of 1803416-28-5

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General Information

  • CAS No. 1803416-28-5
  • Cat. No. CS-0097613
  • Purity ≥95%
  • MDL No. None
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₅H₁₁F₃N₂O
  • Molecular Weight 292.26
  • Synonym(s) 2-[(4S)-4,5-dihydro-4-phenyl-2-oxazolyl]-5-(trifluoromethyl)-Pyridine
  • SMILES FC(F)(F)C1=CN=C(C2=N[C@@H](C3=CC=CC=C3)CO2)C=C1

Description

(S)-5-CF3-Pyox-Ph features a chiral pyrrolidinone core bearing a para-trifluoromethylphenyl group, delivering enhanced electron-withdrawing character and improved metabolic stability. This configuration enables efficient incorporation into bioactive scaffolds, particularly in medicinal chemistry applications requiring stereocontrolled synthesis and resistance to oxidative degradation.

Application

(S)-5-CF₃-Pyox-Ph serves as a versatile chiral building block for the synthesis of fluorinated heterocycles and bioactive molecules. Its trifluoromethyl-substituted pyridoxal motif enables robust reactivity in nucleophilic additions and condensation reactions, offering enhanced metabolic stability and lipophilicity. The stereochemically defined center facilitates enantioselective transformations, while the bench-stable, crystalline nature simplifies handling and purification in multi-step syntheses.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

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Computational Chemistry Data

  • TPSA   34.48
  • LogP   3.6185
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   2

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