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CS-W001157 4
Total: USD 88.00

3-(Difluoromethyl)-1-methyl-1H-pyrazol-4-amine

  • CAS No. 1801762-09-3

  • Cat. No. CS-0499416
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

3-(Difluoromethyl)-1-methyl-1H-pyrazol-4-amine|CS-0499416

Structure of 1801762-09-3

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General Information

  • CAS No. 1801762-09-3
  • Cat. No. CS-0499416
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₇F₂N₃
  • Molecular Weight 147.13
  • Synonym(s) None
  • SMILES CN1C=C(N)C(=N1)C(F)F

Description

3-(Difluoromethyl)-1-methyl-1H-pyrazol-4-amine features a difluoromethyl group that enhances metabolic stability and membrane permeability. This electron-deficient pyrazole scaffold integrates readily into bioactive molecules, serving as a key building block for pharmaceutical intermediates and agrochemicals requiring fluorinated heterocyclic motifs.

Application

3-(Difluoromethyl)-1-methyl-1H-pyrazol-4-amine serves as a versatile building block in medicinal chemistry, enabling the incorporation of a polar, metabolically stable difluoromethyl group adjacent to a hydrogen-bonding pyrazole nitrogen. Its compatibility with standard cross-coupling reactions and functional group tolerance facilitates efficient access to diverse heterocyclic scaffolds for drug discovery applications.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362

Quality Control

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Computational Chemistry Data

  • TPSA   43.84
  • LogP   0.9399
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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