Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

tert-Butyl 4-oxo-3,4-dihydroquinoline-1(2H)-carboxylate

  • CAS No. 179898-00-1

  • Cat. No. CS-0035613
  • Purity≥97%
  • MDL No.MFCD10697721

*For research and further manufacturing use only, not for direct human use.

tert-Butyl 4-oxo-3,4-dihydroquinoline-1(2H)-carboxylate|CS-0035613

Structure of 179898-00-1

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 179898-00-1
  • Cat. No. CS-0035613
  • Purity ≥97%
  • MDL No. MFCD10697721
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₄H₁₇NO₃
  • Molecular Weight 247.29
  • Synonym(s) N-Boc-3,4-dihydroquinoline-4(2H)-one
  • SMILES CC(C)(C)OC(=O)N1CCC(=O)C2=CC=CC=C21

Description

tert-Butyl 4-oxo-3,4-dihydroquinoline-1(2H)-carboxylate features a rigid, electron-deficient quinoline core with a masked carbonyl functionality, enabling direct incorporation into synthetic sequences without pre-activation. This bench-stable derivative facilitates efficient access to complex heterocycles through controlled cyclization or coupling reactions under standard conditions.

Application

tert-Butyl 4-oxo-3,4-dihydroquinoline-1(2H)-carboxylate serves as a versatile scaffold for the synthesis of quinoline-based heterocycles, enabling efficient access to medicinally relevant architectures. Its functionality supports diverse transformations including nucleophilic additions, reductive aminations, and transition-metal-catalyzed couplings. The tert-butyl ester group provides excellent bench stability and facilitates straightforward deprotection under mild acidic conditions, enhancing its utility in multi-step synthetic sequences.

Synthesis

  • Route1

    References

    • SCHERING CORPORATION Patent: WO2009/52288 A1, 2009 ; Location in patent: Page/Page column 395 ;
  • Route2

    References

    • Catino, Arthur J.; Nichols, Jason M.; Choi, Hojae; Gottipamula, Sidhartha; Doyle, Michael P. Organic Letters, 2005 , vol. 7, # 23 p. 5167 - 5170
  • Route3
    • null|null
      1407968-48-2
    • ~65%
    • In-stock
      tert-Butyl 4-oxo-3,4-dihydroquinoline-1(2H)-carboxylate|CS-0035613
      179898-00-1

    References

    • Sole, Daniel; Mariani, Francesco; Fernandez, Israel; Sierra, Miguel A. Journal of Organic Chemistry, 2012 , vol. 77, # 22 p. 10272 - 10284

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   46.61
  • LogP   3.0145
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   0

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 179898-00-1 sigma179898-00-1 manufacturer179898-00-1 price179898-00-1 structure179898-00-1 SDSbuy 179898-00-1179898-00-1 supplier179898-00-1 uses179898-00-1 molecular weightprice of 179898-00-1179898-00-1 chemical name formula of 179898-00-1
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label