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CS-W001157 4
Total: USD 88.00

2-Fluoro-3-nitrophenol

  • CAS No. 179816-26-3

  • Cat. No. CS-W006025
  • Purity≥98%
  • MDL No.MFCD11042443

*For research and further manufacturing use only, not for direct human use.

2-Fluoro-3-nitrophenol|CS-W006025

Structure of 179816-26-3

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General Information

  • CAS No. 179816-26-3
  • Cat. No. CS-W006025
  • Purity ≥98%
  • MDL No. MFCD11042443
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄FNO₃
  • Molecular Weight 157.10
  • Synonym(s) 2-fluoranyl-3-nitro-phenol
  • SMILES FC1=C([N+]([O-])=O)C=CC=C1O

Description

2-Fluoro-3-nitrophenol features a fluorine atom at the ortho position and a nitro group at the meta position relative to the phenolic hydroxyl, creating a strongly electron-deficient aromatic system. This combination enhances reactivity in electrophilic substitution and facilitates coupling reactions under mild conditions. The compound exhibits bench-stable handling characteristics and serves as a key intermediate in pharmaceutical synthesis and functional material design.

Application

2-Fluoro-3-nitrophenol serves as a versatile building block in synthetic organic chemistry, enabling direct functionalization at the phenolic oxygen and ortho-fluorine site. Its dual electrophilic handles facilitate nucleophilic aromatic substitution and transition-metal-catalyzed coupling reactions. The molecule exhibits bench stability and tolerates a range of reaction conditions, simplifying purification and integration into complex molecular architectures such as heterocyclic scaffolds and pharmaceutical intermediates.

Safety Information

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GHS Pictogram :
GHS No : GHS05,GHS07,GHS09
Signal Word : Danger
UN#: 3077
Class : 9
Packing Group : Ⅲ
Hazard Statements : H302-H315-H317-H318-H410
Precautionary Statements : P261-P264-P270-P272-P273-P280-P302+P352-P330-P362+P364-P391-P501

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Computational Chemistry Data

  • TPSA   63.37
  • LogP   1.4395
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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