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CS-W001157 4
Total: USD 88.00

3-Bromo-1,8-naphthyridine

  • CAS No. 17965-78-5

  • Cat. No. CS-0059184
  • Purity≥96%
  • MDL No.MFCD04113794

*For research and further manufacturing use only, not for direct human use.

3-Bromo-1,8-naphthyridine|CS-0059184

Structure of 17965-78-5

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General Information

  • CAS No. 17965-78-5
  • Cat. No. CS-0059184
  • Purity ≥96%
  • MDL No. MFCD04113794
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₅BrN₂
  • Molecular Weight 209.05
  • Synonym(s) 1,8-naphthyridine, 3-bromo-
  • SMILES BrC1=CC2=CC=CN=C2N=C1

Description

3-Bromo-1,8-naphthyridine is a bench-stable heterocyclic building block featuring a bromine atom at the 3-position of the naphthyridine core. This electron-deficient scaffold facilitates efficient cross-coupling reactions and integrates readily into pharmaceutical and materials chemistry platforms.

Application

3-Bromo-1,8-naphthyridine serves as a versatile building block in medicinal chemistry and materials science, enabling palladium-catalyzed cross-coupling reactions such as Suzuki, Stille, and Negishi transformations. Its bromine substituent offers high reactivity and compatibility with diverse functional groups, while the fused heterocyclic core provides structural rigidity and favorable electronic properties for targeted molecular design. The compound exhibits excellent bench stability and is readily purified by recrystallization or column chromatography, making it well-suited for scalable synthesis and downstream applications in API development and advanced ligand construction.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   25.78
  • LogP   2.3923
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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