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CS-W001157 4
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1-(3-Fluorophenyl)cyclobutanecarboxylic acid

  • CAS No. 179411-84-8

  • Cat. No. CS-0196872
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

1-(3-Fluorophenyl)cyclobutanecarboxylic acid|CS-0196872

Structure of 179411-84-8

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General Information

  • CAS No. 179411-84-8
  • Cat. No. CS-0196872
  • Purity ≥95%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₁FO₂
  • Molecular Weight 194.20
  • Synonym(s) Cyclobutanecarboxylic acid, 1-(3-fluorophenyl)-
  • SMILES C1=CC(=CC(=C1)F)C2(CCC2)C(=O)O

Description

1-(3-Fluorophenyl)cyclobutanecarboxylic acid features a rigid cyclobutanecarboxylic acid core linked to a fluorinated phenyl ring, delivering enhanced metabolic stability and improved membrane permeability. This structural motif integrates well into bioactive scaffolds requiring precise spatial orientation and moderate lipophilicity.

Application

1-(3-Fluorophenyl)cyclobutanecarboxylic acid serves as a versatile building block for medicinal chemistry and pharmaceutical process development, enabling the synthesis of bioactive molecules through standard coupling reactions. Its cyclobutane core provides conformational rigidity, while the ortho-fluorinated phenyl group offers enhanced metabolic stability and modulated lipophilicity. The carboxylic acid functionality facilitates direct derivatization or amide formation, and the compound exhibits good bench stability and ease of purification in routine synthetic workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   37.3
  • LogP   2.332
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   2

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