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CS-W001157 4
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1-(Pyrazin-2-yl)ethanamine

  • CAS No. 179323-60-5

  • Cat. No. CS-B0644
  • Molecule weight123.16
  • Purity≥95%
  • MDL No.MFCD11506006

*For research and further manufacturing use only, not for direct human use.

1-(Pyrazin-2-yl)ethanamine|CS-B0644

Structure of 179323-60-5

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General Information

  • CAS No. 179323-60-5
  • Cat. No. CS-B0644
  • Purity ≥95%
  • MDL No. MFCD11506006
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₉N₃
  • Molecular Weight 123.16
  • Synonym(s) alpha-Methyl-2-pyrazinemethanamine
  • SMILES NC(C)C1=NC=CN=C1

Description

1-(Pyrazin-2-yl)ethanamine features a pyrazine ring linked to an ethylamine side chain, offering a versatile nitrogen-rich scaffold. This compound integrates readily into medicinal chemistry projects due to its electron-deficient heterocyclic core and amine functionality. The molecule exhibits favorable solubility and stability under standard conditions, enabling efficient coupling reactions in synthetic workflows.

Application

1-(Pyrazin-2-yl)ethanamine serves as a versatile building block for medicinal chemistry and catalyst development, enabling direct incorporation of the pyrazine ring into bioactive molecules. Its primary amine functionality facilitates facile derivatization via acylation, alkylation, and coupling reactions, while the pyrazine core offers enhanced metabolic stability and favorable pharmacokinetic properties. The compound exhibits good bench stability and is readily purified by standard chromatographic methods, making it well-suited for high-throughput synthesis and scale-up applications.

Synthesis

  • Route1
    • Acetylpyrazine, ≥99%|CS-1269018
      22047-25-2
    • ~72%
    • In-stock
      1-(Pyrazin-2-yl)ethanamine|CS-B0644
      179323-60-5

    References

    • Roche Palo Alto LLC Patent: US2009/170873 A1, 2009 ; Location in patent: Page/Page column 43-44 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   51.8
  • LogP   0.4963
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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