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Structure of 17878-44-3
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(4-Bromophenoxy)trimethylsilane features a brominated phenoxy group tethered to a trimethylsilyl moiety, enabling robust protection and selective functionalization. This bench-stable reagent facilitates efficient silicon-directed ortho-activation in cross-coupling reactions and serves as a key intermediate in the synthesis of silyl-protected aryl building blocks for pharmaceutical and materials applications.
(4-Bromophenoxy)trimethylsilane serves as a stable, bench-ready silyl ether protecting group for phenols, enabling selective deprotection under mild conditions. It facilitates efficient Suzuki-Miyaura and Stille coupling reactions through the pendant bromoaryl functionality, offering orthogonal reactivity in complex molecule synthesis. The trimethylsilyl group provides excellent stability during standard organic transformations while allowing straightforward removal with fluoride sources.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: