tert-Butyl (4-(2-hydroxypropan-2-yl)phenyl)carbamate

Name: tert-Butyl (4-(2-hydroxypropan-2-yl)phenyl)carbamate
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CAS No. 1787261-03-3
Cat. No. CS-0254179
Purity≥98%
MDL No.None

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tert-Butyl (4-(2-hydroxypropan-2-yl)phenyl)carbamate|CS-0254179

Structure of 1787261-03-3

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General Information

CAS No. 1787261-03-3
Cat. No. CS-0254179
Purity ≥98%
MDL No. None
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₄H₂₁NO₃
Molecular Weight 251.32
Synonym(s) [4-(1-Hydroxy-1-methyl-ethyl)-phenyl]-carbamic acid tert-butyl ester
SMILES O=C(OC(C)(C)C)NC1=CC=C(C(C)(O)C)C=C1

Description

tert-Butyl (4-(2-hydroxypropan-2-yl)phenyl)carbamate features a sterically shielded tert-butyl carbamate group attached to a para-substituted phenyl ring bearing a tertiary alcohol. This combination imparts exceptional bench stability and moisture tolerance, enabling reliable use in iterative synthesis workflows. The protected amine functionality integrates seamlessly into multi-step sequences without decomposition.

Application

tert-Butyl (4-(2-hydroxypropan-2-yl)phenyl)carbamate serves as a stable, bench-ready protecting group for aniline derivatives, enabling selective amidation and subsequent deprotection under mild acidic conditions. The tert-butyl carbamate moiety offers excellent functional group tolerance and facilitates purification via standard chromatographic methods. Its ortho-substituted aryl scaffold supports downstream coupling reactions in medicinal chemistry workflows, particularly in the synthesis of biaryl-based scaffolds and kinase inhibitors.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362

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Computational Chemistry Data

TPSA 58.56
LogP 3.261
H_Acceptors 3
H_Donors 2
Rotatable_Bonds 2

Other Classifications

Building Blocks Functional Group Alcohol

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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tert-Butyl (4-(2-hydroxypropan-2-yl)phenyl)carbamate

CAS No. 1787261-03-3

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