3-(3,4-Dimethoxyphenyl)-1-(3-hydroxyphenyl)propan-1-one

Name: 3-(3,4-Dimethoxyphenyl)-1-(3-hydroxyphenyl)propan-1-one
Brand: ChemScene
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CAS No. 178445-83-5
Cat. No. CS-0126652
Purity≥98%
MDL No.MFCD06245367

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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3-(3,4-Dimethoxyphenyl)-1-(3-hydroxyphenyl)propan-1-one|CS-0126652

Structure of 178445-83-5

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Description

This chalcone derivative features a conjugated enone system flanked by electron-rich aromatic rings, enhancing its stability and reactivity in synthetic transformations. The 3,4-dimethoxyphenyl moiety imparts solubility and resistance to oxidation, while the phenolic hydroxyl group enables further derivatization or metal coordination. Designed for use in natural product synthesis and medicinal chemistry screening.

Application

3-(3,4-Dimethoxyphenyl)-1-(3-hydroxyphenyl)propan-1-one serves as a versatile scaffold for the synthesis of bioactive molecules, leveraging its conjugated enone system and multiple aromatic functional groups. The molecule enables efficient Michael additions, electrophilic substitutions, and transition-metal-catalyzed couplings due to its well-defined reactivity profile. Bench-stable and readily purified via crystallization, it functions as a key building block in natural product analogs and pharmaceutical intermediates requiring ortho-hydroxyl and methoxy-directed transformations.

General Information

CAS No. 178445-83-5
Cat. No. CS-0126652
Purity ≥98%
MDL No. MFCD06245367
Storage RT, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₇H₁₈O₄
Molecular Weight 286.32
Synonym(s) 3-(3,4-Dimethoxyphenyl)-1-(3-hydroxyphenyl)-1-propenone
SMILES O=C(C1=CC=CC(O)=C1)CCC2=CC=C(OC)C(OC)=C2

Computational Chemistry Data

TPSA 55.76
LogP 3.2249
H_Acceptors 4
H_Donors 1
Rotatable_Bonds 6

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P233-P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501

Quality Control

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Other Classifications

Building Blocks Functional Group Ketone

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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3-(3,4-Dimethoxyphenyl)-1-(3-hydroxyphenyl)propan-1-one

CAS No. 178445-83-5

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