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CS-W001157 4
Total: USD 88.00

tert-Butyl 4-(hydroxymethyl)benzoate

  • CAS No. 143726-85-6

  • Cat. No. CS-W007293
  • Purity≥96%
  • MDL No.MFCD04973449

*For research and further manufacturing use only, not for direct human use.

tert-Butyl 4-(hydroxymethyl)benzoate|CS-W007293

Structure of 143726-85-6

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General Information

  • CAS No. 143726-85-6
  • Cat. No. CS-W007293
  • Purity ≥96%
  • MDL No. MFCD04973449
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₆O₃
  • Molecular Weight 208.25
  • Synonym(s) 4-HYDROXY-METHYL-BENZOIC ACID MONO TERT-BUTYL ESTER
  • SMILES O=C(OC(C)(C)C)C1=CC=C(CO)C=C1

Description

tert-Butyl 4-(hydroxymethyl)benzoate features a para-hydroxymethyl group appended to a tert-butyl-protected benzoate scaffold, enabling direct functionalization at the aromatic ring. This bench-stable derivative integrates seamlessly into synthetic sequences requiring orthogonal protection and subsequent deprotection under mild acidic conditions.

Application

tert-Butyl 4-(hydroxymethyl)benzoate serves as a versatile benzyl alcohol derivative, enabling direct functionalization at the benzylic position via oxidation or protection. Its tert-butyl ester group provides excellent bench stability and facilitates straightforward deprotection under mild acidic conditions. The molecule exhibits robust compatibility with diverse reaction conditions, making it a reliable building block for pharmaceutical intermediates and heterocyclic scaffold construction.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   46.53
  • LogP   2.1342
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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