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2-Bromo-5-chloro-[1,2,4]triazolo[1,5-a]pyridine

  • CAS No. 1784176-14-2

  • Cat. No. CS-0480074
  • Molecule weight232.47
  • Purity≥98%
  • MDL No.MFCD27918582

*For research and further manufacturing use only, not for direct human use.

2-Bromo-5-chloro-[1,2,4]triazolo[1,5-a]pyridine|CS-0480074

Structure of 1784176-14-2

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General Information

  • CAS No. 1784176-14-2
  • Cat. No. CS-0480074
  • Purity ≥98%
  • MDL No. MFCD27918582
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₃BrClN₃
  • Molecular Weight 232.47
  • Synonym(s) None
  • SMILES BrC1=NN2C(C=CC=C2Cl)=N1

Description

2-Bromo-5-chloro-[1,2,4]triazolo[1,5-a]pyridine features a fused triazolopyridine core bearing bromo and chloro substituents at electron-deficient positions, enabling direct functionalization in cross-coupling reactions. This scaffold delivers high reactivity under standard palladium-catalyzed conditions, facilitating rapid access to complex heterocyclic architectures. The molecule exhibits bench-stable handling characteristics and compatibility with diverse reaction media.

Application

2-Bromo-5-chloro-[1,2,4]triazolo[1,5-a]pyridine serves as a versatile heterocyclic building block for constructing complex nitrogen-rich scaffolds. Its dual halogen substituents enable sequential cross-coupling reactions, facilitating the assembly of biaryl and functionalized triazolopyridine architectures. The compound exhibits excellent bench stability and compatibility with palladium-catalyzed transformations, making it well-suited for medicinal chemistry and process development applications.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   30.19
  • LogP   2.1452
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   0

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