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CS-W001157 4
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7-Fluoro-1H-indazole-4-carboxylic acid

  • CAS No. 1783619-00-0

  • Cat. No. CS-0160502
  • Molecule weight180.14
  • Purity≥98%
  • MDL No.MFCD31728867

*For research and further manufacturing use only, not for direct human use.

7-Fluoro-1H-indazole-4-carboxylic acid|CS-0160502

Structure of 1783619-00-0

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General Information

  • CAS No. 1783619-00-0
  • Cat. No. CS-0160502
  • Purity ≥98%
  • MDL No. MFCD31728867
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₅FN₂O₂
  • Molecular Weight 180.14
  • Synonym(s) None
  • SMILES O=C(C1=CC=C(F)C2=C1C=NN2)O

Description

7-Fluoro-1H-indazole-4-carboxylic acid features a fluorinated indazole core with a carboxylic acid at the 4-position, enabling direct conjugation or derivatization in medicinal chemistry. This electron-deficient heterocycle enhances metabolic stability and modulates target binding affinity. The molecule exhibits excellent solubility in polar solvents and maintains bench-stability under standard conditions.

Application

7-Fluoro-1H-indazole-4-carboxylic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles through standard amide coupling, Suzuki-Miyaura, and Buchwald-Hartwig transformations. Its fluorinated indazole core provides enhanced metabolic stability and modulated electronic properties, while the carboxylic acid group facilitates direct derivatization or conjugation in API development workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   65.98
  • LogP   1.4002
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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