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CS-W001157 4
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Quinazoline-8-carboxylic acid

  • CAS No. 1783401-69-3

  • Cat. No. CS-0489343
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

Quinazoline-8-carboxylic acid|CS-0489343

Structure of 1783401-69-3

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General Information

  • CAS No. 1783401-69-3
  • Cat. No. CS-0489343
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₆N₂O₂
  • Molecular Weight 174.16
  • Synonym(s) None
  • SMILES OC(=O)C1=CC=CC2=CN=CN=C12

Description

Quinazoline-8-carboxylic acid features a rigid heteroaromatic core with a carboxylic acid group at the 8-position, enabling direct conjugation or derivatization in medicinal chemistry. This scaffold integrates readily into bioactive molecules, offering enhanced solubility and hydrogen-bonding capacity for target engagement. The electron-deficient quinazoline ring facilitates π-stacking interactions, supporting potency in kinase inhibitor design.

Application

Quinazoline-8-carboxylic acid serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles through standard functional group manipulations. Its carboxylic acid moiety facilitates amide coupling, esterification, and derivatization under mild conditions, while the quinazoline core provides structural rigidity and π-electron delocalization beneficial for target binding. Bench-stable and readily purified by recrystallization, it functions effectively in both small-molecule synthesis and high-throughput screening campaigns.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H312-H332
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P501

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Computational Chemistry Data

  • TPSA   63.08
  • LogP   1.328
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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