Methyl 3-amino-2,2-dimethylpropanoate hydrochloride

Name: Methyl 3-amino-2,2-dimethylpropanoate hydrochloride
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CAS No. 177269-37-3
Cat. No. CS-W018801
Purity≥97%
MDL No.MFCD10758092

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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Methyl 3-amino-2,2-dimethylpropanoate hydrochloride|CS-W018801

Structure of 177269-37-3

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Description

Methyl 3-amino-2,2-dimethylpropanoate hydrochloride features a sterically hindered quaternary carbon center and a protonated primary amine, enhancing solubility and stability in protic solvents. This bench-stable derivative facilitates efficient coupling reactions in peptide synthesis and medicinal chemistry workflows.

Application

Methyl 3-amino-2,2-dimethylpropanoate hydrochloride serves as a versatile building block in medicinal chemistry, enabling the synthesis of sterically hindered amino acid analogs and heterocyclic scaffolds. Its tertiary α-carbon prevents racemization during peptide coupling, while the protonated amine enhances solubility and facilitates purification. The ester group supports subsequent transformations such as hydrolysis or nucleophilic substitution, making it ideal for robust, scalable synthetic routes.

General Information

CAS No. 177269-37-3
Cat. No. CS-W018801
Purity ≥97%
MDL No. MFCD10758092
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₁₄ClNO₂
Molecular Weight 167.63
Synonym(s) Methyl 3-amino-2,2-dimethylpropanoatehydrochloride
SMILES COC(C(C)(CN)C)=O.Cl

Computational Chemistry Data

TPSA 52.32
LogP 0.5661
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 2

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Functional Group Ester

Building Blocks Skeleton Fatty chain compounds

Key Words

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Methyl 3-amino-2,2-dimethylpropanoate hydrochloride

CAS No. 177269-37-3

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