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CS-W001157 4
Total: USD 88.00

2-Amino-6-methylphenol

  • CAS No. 17672-22-9

  • Cat. No. CS-W009306
  • Purity≥97%
  • MDL No.MFCD03788432

*For research and further manufacturing use only, not for direct human use.

2-Amino-6-methylphenol|CS-W009306

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General Information

  • CAS No. 17672-22-9
  • Cat. No. CS-W009306
  • Purity ≥97%
  • MDL No. MFCD03788432
  • Storage 4°C, protect from light, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₉NO
  • Molecular Weight 123.16
  • Synonym(s) 6-AMINO-2-METHYL PHENOL
  • SMILES NC1=CC=CC(=C1O)C

Description

2-Amino-6-methylphenol serves as a key intermediate in the synthesis of pharmaceuticals and specialty dyes. This ortho-substituted aromatic compound features a nucleophilic amino group flanked by a methyl group and a hydroxyl moiety, enhancing its reactivity in electrophilic substitution reactions. The molecule exhibits moderate solubility in polar solvents and maintains stability under standard bench conditions.

Application

2-Amino-6-methylphenol serves as a versatile building block in synthetic organic chemistry, enabling access to substituted heterocycles and bioactive scaffolds. Its ortho-amino and phenolic functionalities offer complementary reactivity for coupling reactions, electrophilic substitutions, and protection strategies. The molecule exhibits good bench stability and facilitates straightforward purification, making it well-suited for medicinal chemistry campaigns and process-scale synthesis.

Synthesis

  • Route1

    References

    • BIOLIPOX AB Patent: WO2008/110793 A1, 2008 ; Location in patent: Page/Page column 104 ;
  • Route2

    References

    • US2007/10670 A1, ; Page/Page column 84 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   46.25
  • LogP   1.28282
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   0

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