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CS-W001157 4
Total: USD 88.00

2,2-Bis[(4S)-4-benzyl-2-oxazolin-2-yl]propane

  • CAS No. 176706-98-2

  • Cat. No. CS-0087136
  • Purity≥95%
  • MDL No.MFCD28038687

*For research and further manufacturing use only, not for direct human use.

2,2-Bis[(4S)-4-benzyl-2-oxazolin-2-yl]propane|CS-0087136

Structure of 176706-98-2

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General Information

  • CAS No. 176706-98-2
  • Cat. No. CS-0087136
  • Purity ≥95%
  • MDL No. MFCD28038687
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₃H₂₆N₂O₂
  • Molecular Weight 362.46
  • Synonym(s) 2,2'-Isopropylidenebis[(4S)-4-benzyl-2-oxazoline]
  • SMILES CC(C1=N[C@@H](CC2=CC=CC=C2)CO1)(C)C3=N[C@@H](CC4=CC=CC=C4)CO3

Description

This chiral bis-oxazoline ligand features two (4S)-4-benzyl-2-oxazolin-2-yl groups attached to a central propane backbone, enabling effective coordination to transition metals in asymmetric catalysis. The sterically defined pocket enhances enantioselectivity in metal-mediated transformations.

Application

2,2-Bis[(4S)-4-benzyl-2-oxazolin-2-yl]propane serves as a robust chiral ligand scaffold for transition metal catalysis, enabling asymmetric transformations through well-defined coordination modes. Its sterically congested bis-oxazoline architecture provides high enantioselectivity in copper- and palladium-catalyzed reactions, including allylic alkylations and cycloadditions. The benzyl groups enhance solubility and stability under standard reaction conditions, facilitating straightforward purification and consistent performance across bench-scale applications.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   43.18
  • LogP   4.0926
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   6

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