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CS-W001157 4
Total: USD 88.00

(3,5-Dichloro-4-methoxyphenyl)boronic acid

  • CAS No. 175883-61-1

  • Cat. No. CS-0176121
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(3,5-Dichloro-4-methoxyphenyl)boronic acid|CS-0176121

Structure of 175883-61-1

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General Information

  • CAS No. 175883-61-1
  • Cat. No. CS-0176121
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇BCl₂O₃
  • Molecular Weight 220.85
  • Synonym(s) 3,5-Dichloro-4-methoxyphenylboronic acid
  • SMILES COC1=C(Cl)C=C(B(O)O)C=C1Cl

Description

This boronic acid features a methoxy-substituted aryl core with ortho-chlorine and para-chlorine directing groups, enabling efficient Suzuki-Miyaura coupling under standard conditions. The electron-withdrawing chlorine atoms enhance stability and reactivity, while the methoxy group improves solubility in polar solvents. This combination delivers reliable performance in complex molecule synthesis.

Application

(3,5-Dichloro-4-methoxyphenyl)boronic acid serves as a versatile building block in Suzuki-Miyaura cross-coupling reactions, enabling efficient construction of biaryl scaffolds with enhanced electronic and steric properties. The dichloro substitution pattern provides predictable regioselectivity, while the methoxy group offers moderate electron donation and improved solubility. Bench-stable and readily purified by recrystallization, it functions reliably in standard coupling protocols across medicinal chemistry and materials synthesis workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   49.69
  • LogP   0.6818
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   2

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