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CS-W001157 4
Total: USD 88.00

4-Amino-3-(trifluoromethoxy)benzoic acid

  • CAS No. 175278-22-5

  • Cat. No. CS-W014741
  • Purity≥97%
  • MDL No.MFCD00205143

*For research and further manufacturing use only, not for direct human use.

4-Amino-3-(trifluoromethoxy)benzoic acid|CS-W014741

Structure of 175278-22-5

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General Information

  • CAS No. 175278-22-5
  • Cat. No. CS-W014741
  • Purity ≥97%
  • MDL No. MFCD00205143
  • Storage RT, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₆F₃NO₃
  • Molecular Weight 221.14
  • Synonym(s) 4-Carboxy-2-(trifluoromethoxy)aniline
  • SMILES O=C(O)C1=CC=C(N)C(OC(F)(F)F)=C1

Description

4-Amino-3-(trifluoromethoxy)benzoic acid features a strategically positioned trifluoromethoxy group that enhances metabolic stability and lipophilicity, while the para-amino functionality enables direct conjugation in peptide synthesis and bioconjugation workflows. This aromatic scaffold integrates seamlessly into pharmaceutical intermediates and functional materials requiring electron-rich, moisture-tolerant platforms under standard bench conditions.

Application

4-Amino-3-(trifluoromethoxy)benzoic acid serves as a versatile building block for medicinal chemistry and agrochemical synthesis, enabling efficient access to bioactive heterocycles. The ortho-amino and carboxylic acid functionalities provide orthogonal reactivity for coupling, amidation, and cyclization reactions. Its stability under standard bench conditions and compatibility with diverse functional groups facilitate straightforward purification and integration into complex molecular architectures.

Synthesis

  • Route1
    • Benzoic acid, 4-amino-3-(trifluoromethoxy)-, methyl ester, hydrochloride|CS-0915551
      1011531-66-0
    • ~%
    • In-stock
      4-Amino-3-(trifluoromethoxy)benzoic acid|CS-W014741
      175278-22-5

    References

    • WO2008/30520 A1, ; Page/Page column 135-136 ; WO 2008/030520 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   72.55
  • LogP   1.8656
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   2

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