Lot numbers can be found on the outside label of a product:
2-Amino-5-bromo-4,6-dimethylpyrimidine
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CAS No. 4214-57-7
- Cat. No. CS-W015525
- Purity≥98%
- MDL No.MFCD00160498
*For research and further manufacturing use only, not for direct human use.
Structure of 4214-57-7
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General Information
- CAS No. 4214-57-7
- Cat. No. CS-W015525
- Purity ≥98%
- MDL No. MFCD00160498
- Storage 4°C, protect from light
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₆H₈BrN₃
- Molecular Weight 202.05
- Synonym(s) 5-BROMO-4,6-DIMETHYLPYRIMIDINE-2-YLAMINE
- SMILES NC1=NC(C)=C(Br)C(C)=N1
Description
2-Amino-5-bromo-4,6-dimethylpyrimidine serves as a key heterocyclic scaffold in medicinal chemistry, featuring a bromine substituent at C5 and methyl groups at C4 and C6. The amino group enables facile functionalization, while the electron-deficient pyrimidine ring supports transition metal-catalyzed coupling reactions under standard conditions. This compound exhibits bench-stable handling characteristics and demonstrates compatibility with diverse synthetic transformations.
Application
2-Amino-5-bromo-4,6-dimethylpyrimidine serves as a versatile building block in heterocyclic synthesis, enabling efficient access to substituted pyrimidines via palladium-catalyzed cross-coupling and nucleophilic substitution reactions. Its well-defined functional groups—bromine at C5 and amino at C2—offer orthogonal reactivity for sequential derivatization, while the methyl substituents enhance stability and facilitate purification. The compound exhibits excellent bench stability and compatibility with standard synthetic workflows, making it a practical choice for medicinal chemistry and API intermediate development.
Synthesis
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Route1
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In-stock
767-15-7 - ~84%
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In-stock
4214-57-7
References
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Arce, Pablo M.; Khdour, Omar M.; Goldschmidt, Ruth; Armstrong, Jeffrey S.; Hecht, Sidney M. ACS Medicinal Chemistry Letters, 2011 , vol. 2, # 8 p. 608 - 613
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Route2
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1122-58-3 - ~85%
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In-stock
4214-57-7
References
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Goldschmidt, Ruth; Arce, Pablo M.; Khdour, Omar M.; Collin, Valerie C.; Dey, Sriloy; Jaruvangsanti, Jennifer; Fash, David M.; Hecht, Sidney M. Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 4 p. 969 - 978
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Route3
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123-54-6 - ~%
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In-stock
4214-57-7
References
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Arce, Pablo M.; Khdour, Omar M.; Goldschmidt, Ruth; Armstrong, Jeffrey S.; Hecht, Sidney M. ACS Medicinal Chemistry Letters, 2011 , vol. 2, # 8 p. 608 - 613
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302
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Precautionary Statements : P264-P270-P330-P501
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Quality Control
Computational Chemistry Data
- TPSA 51.8
- LogP 1.43814
- H_Acceptors 3
- H_Donors 1
- Rotatable_Bonds 0
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Key Words
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