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Structure of 175205-77-3
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4-Chloro-2-(trifluoromethoxy)aniline features a trifluoromethoxy group that enhances electron-withdrawal and metabolic stability, while the ortho-chloro substituent provides steric and electronic modulation. This aniline derivative serves as a key building block in pharmaceutical intermediates and agrochemicals, offering improved solubility and reactivity under standard conditions.
4-Chloro-2-(trifluoromethoxy)aniline serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling efficient construction of heterocyclic scaffolds via standard coupling reactions. Its trifluoromethoxy group enhances metabolic stability and lipophilicity, while the chloro substituent facilitates palladium-catalyzed cross-coupling transformations. The compound exhibits good bench stability and is compatible with common protecting group strategies, supporting streamlined synthetic workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: