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Structure of 17515-74-1
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This trifluoromethyl-substituted furan carboxylic acid features enhanced electron-withdrawing character and improved metabolic stability. The methyl group at the 5-position introduces steric modulation, while the para-trifluoromethyl moiety imparts strong lipophilicity and resistance to oxidative degradation. Ideal for medicinal chemistry scaffolds requiring robust heterocyclic frameworks with tunable solubility profiles.
5-Methyl-2-(trifluoromethyl)furan-3-carboxylic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles due to its orthogonal reactivity profile. The trifluoromethyl group enhances metabolic stability and lipophilicity, while the carboxylic acid facilitates direct coupling reactions. Its bench-stable nature and compatibility with standard amide bond formation protocols make it ideal for constructing complex scaffolds in API development.
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GHS Pictogram :
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GHS No : GHS05
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Signal Word : Danger
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UN#: 3261
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Class : 8
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Packing Group : Ⅲ
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Hazard Statements : H314-H318
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Precautionary Statements : P280-P301+P330+P331
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Lot numbers can be found on the outside label of a product: