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CS-W001157 4
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3-(Chloromethyl)cyclobutanone

  • CAS No. 175021-13-3

  • Cat. No. CS-0054362
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

3-(Chloromethyl)cyclobutanone|CS-0054362

Structure of 175021-13-3

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General Information

  • CAS No. 175021-13-3
  • Cat. No. CS-0054362
  • Purity ≥95%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₇ClO
  • Molecular Weight 118.56
  • Synonym(s) 3-(chloromethyl)cyclobutan-1-one
  • SMILES O=C1CC(CCl)C1

Description

3-(Chloromethyl)cyclobutanone is a reactive cyclobutanone derivative featuring a chloromethyl group that enables efficient functionalization. This electrophilic handle facilitates nucleophilic substitution and conjugate addition reactions, serving as a key intermediate in the synthesis of complex cyclic architectures. The strained ring system enhances reactivity while maintaining stability under standard handling conditions.

Application

3-(Chloromethyl)cyclobutanone serves as a versatile building block for the construction of functionalized cyclobutane scaffolds. The chloromethyl group enables nucleophilic substitution reactions, while the ketone functionality supports enolate chemistry and reductive transformations. Its bench-stable nature and compatibility with diverse reaction conditions facilitate efficient synthesis of complex heterocycles and medicinally relevant frameworks in organic and medicinal chemistry workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H225
Precautionary Statements : P210-P243-P273-P403

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Computational Chemistry Data

  • TPSA   17.07
  • LogP   1.2043
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   1

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