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CS-W001157 4
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(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)methanamine

  • CAS No. 17413-10-4

  • Cat. No. CS-W006229
  • Purity≥98%
  • MDL No.MFCD02677684

*For research and further manufacturing use only, not for direct human use.

(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)methanamine|CS-W006229

Structure of 17413-10-4

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General Information

  • CAS No. 17413-10-4
  • Cat. No. CS-W006229
  • Purity ≥98%
  • MDL No. MFCD02677684
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₁NO₂
  • Molecular Weight 165.19
  • Synonym(s) 2,3-DIHYDRO-1,4-BENZODIOXIN-6-YLMETHYLAMINE
  • SMILES NCC1=CC=C(OCCO2)C2=C1

Description

This bench-stable amine features a rigid, electron-rich dihydrodioxin scaffold that enhances solubility and metabolic stability. The methanamine group provides a versatile handle for conjugation, enabling efficient integration into bioactive molecules and functional materials under standard conditions.

Application

(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)methanamine serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles through amine-directed functionalization. Its stable dihydrobenzodioxin core offers favorable solubility and metabolic stability, while the primary amine facilitates conjugation via amidation, alkylation, or reductive amination. The scaffold exhibits excellent functional group tolerance and is compatible with standard synthetic workflows, making it well-suited for lead optimization and API intermediate development.

Synthesis

  • Route1

    References

    • US2010/298351 A1, ; Page/Page column 34 ; US 20100298351 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   44.48
  • LogP   0.9165
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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