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CS-W001157 4
Total: USD 88.00

1-[4-(Trifluoromethyl)phenyl]ethanol

  • CAS No. 1737-26-4

  • Cat. No. CS-0067774
  • Purity≥97%
  • MDL No.MFCD00039618

*For research and further manufacturing use only, not for direct human use.

1-[4-(Trifluoromethyl)phenyl]ethanol|CS-0067774

Structure of 1737-26-4

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General Information

  • CAS No. 1737-26-4
  • Cat. No. CS-0067774
  • Purity ≥97%
  • MDL No. MFCD00039618
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₉F₃O
  • Molecular Weight 190.16
  • Synonym(s) ALPHA-METHYL-4-(TRIFLUOROMETHYL) BENZYL ALCOHOL, TECH.,
  • SMILES CC(O)C1=CC=C(C(F)(F)F)C=C1

Description

1-[4-(Trifluoromethyl)phenyl]ethanol features a trifluoromethyl-substituted aryl ring paired with a benzylic alcohol functionality, enabling direct integration into pharmaceutical intermediates and functional materials. The electron-withdrawing trifluoromethyl group enhances metabolic stability while the hydroxyl moiety offers a handle for derivatization under standard conditions. This bench-stable compound serves as a key building block in synthetic routes requiring aromatic alcohols with tuned electronic properties.

Application

1-[4-(Trifluoromethyl)phenyl]ethanol serves as a versatile building block in medicinal chemistry, enabling the synthesis of biologically active aryl-alkanol scaffolds. Its trifluoromethyl group imparts enhanced metabolic stability and lipophilicity, while the secondary alcohol facilitates straightforward derivatization via oxidation, protection, or coupling reactions. The compound exhibits good bench stability and is readily purified by distillation or chromatography, making it well-suited for scalable synthesis and process development.

Synthesis

  • Route1

    References

    • Journal of Organic Chemistry, , vol. 65, # 23 p. 8123 - 8125
  • Route2
    • In-stock
      1-[4-(Trifluoromethyl)phenyl]ethanol|CS-0067774
      1737-26-4
    • ~46%
    • In-stock
      1-(4-(Trifluoromethyl)phenyl)ethanone|CS-W007473
      709-63-7
    • In-stock
      1-[4-(Trifluoromethyl)phenyl]ethanol|CS-0067774
      1737-26-4

    References

    • Mizoguchi, Hirotaka; Uchida, Tatsuya; Katsuki, Tsutomu Angewandte Chemie - International Edition, 2014 , vol. 53, # 12 p. 3178 - 3182 Angew. Chem., 2014 , vol. 126, # 12 p. 3242 - 3246,5
  • Route3
    • null|null
      936752-34-0
    • ~%
    • In-stock
      1-[4-(Trifluoromethyl)phenyl]ethanol|CS-0067774
      1737-26-4

    References

    • Organic Letters, , vol. 9, # 9 p. 1659 - 1661

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P302+P352-P304+P340

Quality Control

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Computational Chemistry Data

  • TPSA   20.23
  • LogP   2.7587
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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