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Structure of 173252-76-1
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5-(Trifluoromethoxy)-2,3-dihydro-1H-inden-1-one features a trifluoromethoxy group at the 5-position of a partially saturated indenone scaffold. This electron-deficient ketone integrates readily into synthetic sequences requiring polar, moisture-tolerant building blocks. The fused ring system provides rigidity and enhanced stability under standard bench conditions.
5-(Trifluoromethoxy)-2,3-dihydro-1H-inden-1-one serves as a versatile building block in medicinal chemistry, enabling efficient access to fluorinated heterocyclic scaffolds. Its trifluoromethoxy group imparts enhanced metabolic stability and lipophilicity, while the reactive ketone facilitates nucleophilic addition, reductive amination, and enolate chemistry. The dihydroindene core offers structural rigidity and compatibility with standard coupling and functionalization protocols, making it valuable for lead optimization in drug discovery.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P280-P302+P352
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Lot numbers can be found on the outside label of a product: