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CS-W001157 4
Total: USD 88.00

1H-Pyrrolo[3,2-b]pyridin-5(4H)-one

  • CAS No. 17322-91-7

  • Cat. No. CS-W021339
  • Purity≥95%
  • MDL No.MFCD11215548

*For research and further manufacturing use only, not for direct human use.

1H-Pyrrolo[3,2-b]pyridin-5(4H)-one|CS-W021339

Structure of 17322-91-7

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General Information

  • CAS No. 17322-91-7
  • Cat. No. CS-W021339
  • Purity ≥95%
  • MDL No. MFCD11215548
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆N₂O
  • Molecular Weight 134.14
  • Synonym(s) 1H-Pyrrolo[3,2-b]pyridin-5-ol
  • SMILES O=C1C=CC(NC=C2)=C2N1

Description

1H-Pyrrolo[3,2-b]pyridin-5(4H)-one is a heterocyclic scaffold featuring a fused pyrrole-pyridine core with a lactam functionality. This electron-deficient system enables direct incorporation into bioactive molecules, offering enhanced metabolic stability and favorable binding interactions in medicinal chemistry applications.

Application

1H-Pyrrolo[3,2-b]pyridin-5(4H)-one serves as a versatile heterocyclic building block in medicinal chemistry, enabling the synthesis of kinase inhibitors and other bioactive scaffolds. Its fused tricyclic structure exhibits good bench stability and functional group tolerance, facilitating downstream derivatization via nucleophilic substitution or palladium-catalyzed coupling. The molecule functions as a key intermediate in the development of targeted therapeutics, particularly where planar aromatic systems with hydrogen-bonding capacity are required.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   48.65
  • LogP   0.8562
  • H_Acceptors   1
  • H_Donors   2
  • Rotatable_Bonds   0

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