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CS-W001157 4
Total: USD 88.00

2-(2-Bromophenyl)propan-2-amine

  • CAS No. 173026-23-8

  • Cat. No. CS-0154625
  • Purity≥97%
  • MDL No.MFCD11109721

*For research and further manufacturing use only, not for direct human use.

2-(2-Bromophenyl)propan-2-amine|CS-0154625

Structure of 173026-23-8

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General Information

  • CAS No. 173026-23-8
  • Cat. No. CS-0154625
  • Purity ≥97%
  • MDL No. MFCD11109721
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₂BrN
  • Molecular Weight 214.10
  • Synonym(s) 2-bromo-α,α-dimethylbenzenemethanamine
  • SMILES CC(C)(C1=CC=CC=C1Br)N

Description

2-(2-Bromophenyl)propan-2-amine features a sterically hindered tertiary amine linked to a brominated phenyl ring, enabling direct incorporation into transition metal-catalyzed coupling reactions. The para-bromo substituent enhances reactivity in palladium-mediated transformations, while the bulky tert-butyl group imparts stability and minimizes side reactions. This structure supports efficient assembly of complex arylamine architectures under mild conditions.

Application

2-(2-Bromophenyl)propan-2-amine serves as a versatile building block for the synthesis of biologically active heterocycles and pharmaceutical intermediates. Its pendant bromine enables facile palladium-catalyzed coupling reactions, while the tertiary amine functionality offers compatibility with standard functional group manipulations. The molecule exhibits good bench stability and facilitates efficient purification, making it well-suited for iterative synthetic workflows in medicinal chemistry and process development.

Synthesis

  • Route1
    • null|null
      173026-22-7
    • ~85%
    • In-stock
      2-(2-Bromophenyl)propan-2-amine|CS-0154625
      173026-23-8

    References

    • Erdelmeier; Tailhan-Lomont; Yadan Journal of Organic Chemistry, 2000 , vol. 65, # 24 p. 8152 - 8157
  • Route2

    References

    • Erdelmeier; Tailhan-Lomont; Yadan Journal of Organic Chemistry, 2000 , vol. 65, # 24 p. 8152 - 8157
  • Route3

    References

    • Toyota, Shinji; Asakura, Mitsuhiro; Futawaka, Tadahiro; Oki, Michinori Bulletin of the Chemical Society of Japan, 1999 , vol. 72, # 8 p. 1879 - 1885

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   26.02
  • LogP   2.6429
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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