Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

2,6-Dichloro-4-hydroxypyridine

  • CAS No. 17228-74-9

  • Cat. No. CS-W004999
  • Purity≥95%
  • MDL No.MFCD00955619

*For research and further manufacturing use only, not for direct human use.

2,6-Dichloro-4-hydroxypyridine|CS-W004999

Structure of 17228-74-9

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 17228-74-9
  • Cat. No. CS-W004999
  • Purity ≥95%
  • MDL No. MFCD00955619
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₃Cl₂NO
  • Molecular Weight 163.99
  • Synonym(s) 4-pyridinol, 2,6-dichloro-
  • SMILES ClC1=NC(=CC(=C1)O)Cl

Description

2,6-Dichloro-4-hydroxypyridine features a pyridine core functionalized with two chlorine substituents at the 2 and 6 positions and a hydroxyl group at the 4 position. This arrangement imparts enhanced electrophilicity at the C4 position, enabling efficient coupling reactions in heterocyclic synthesis. The compound exhibits bench-stable handling characteristics and serves as a key intermediate for pharmaceutical and agrochemical derivatives requiring regioselective functionalization.

Application

2,6-Dichloro-4-hydroxypyridine serves as a versatile building block for the synthesis of pyridine-based pharmaceutical intermediates and agrochemicals. The hydroxyl group enables direct derivatization via etherification or esterification, while the dichloro substituents facilitate nucleophilic aromatic substitution under mild conditions, allowing efficient access to diverse substituted pyridines. Its bench-stable nature and compatibility with common reaction protocols make it a practical choice for iterative synthetic workflows in medicinal chemistry and process development.

Synthesis

  • Route1

    References

    • Journal of the American Chemical Society, , vol. 125, # 26 p. 7792 - 7793
  • Route2

    References

    • Journal of the American Chemical Society, , vol. 125, # 26 p. 7792 - 7793
  • Route3
    • In-stock
      2,6-Dichloro-1-fluoropyridin-1-ium trifluoromethanesulfonate|CS-0460079
      130433-68-0
    • ~6%
    • In-stock
      2,6-Dichloro-4-hydroxypyridine|CS-W004999
      17228-74-9
    • null|null
      135183-03-8

    References

    • Bulletin of the Chemical Society of Japan, , vol. 64, # 4 p. 1081 - 1092

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   33.12
  • LogP   2.094
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 2,6-Dichloro-4-hydroxypyridine sigma2,6-Dichloro-4-hydroxypyridine manufacturer2,6-Dichloro-4-hydroxypyridine price2,6-Dichloro-4-hydroxypyridine structure2,6-Dichloro-4-hydroxypyridine SDSbuy 2,6-Dichloro-4-hydroxypyridine2,6-Dichloro-4-hydroxypyridine supplier2,6-Dichloro-4-hydroxypyridine uses2,6-Dichloro-4-hydroxypyridine molecular weightprice of 2,6-Dichloro-4-hydroxypyridine2,6-Dichloro-4-hydroxypyridine chemical name formula of 2,6-Dichloro-4-hydroxypyridine
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label